Garth Greenan Gallery is committed to mounting important exhibitions and maintaining a high standard of integrity and connoisseurship. It champions the work of established artists whose work deserves greater recognition, many of whom emerged during the 1960s and 1970s. By re-presenting and recontextualizing their work, the gallery questions the prevailing narrative of contemporary art history and encourages its revision. More recently, the gallery has expanded its mission to include a multigenerational group of Indigenous artists whose work is of both art historical and contemporary relevance. 

Currently, Garth Greenan Gallery represents 27 artists working in a variety of media, including painting, sculpture, drawing, and printmaking. Each year, the gallery presents seven exhibitions, many of which are accompanied by publications.

The gallery is a member of the Art Dealers Association of America.